1/29/2024 0 Comments Hand mirrorAlthough more frequently related to lymphoid malignancies, our case shows that hand-mirror morphology can also be observed in acute myeloid leukemia, thus emphasizing the lack of specificity of this finding in the diagnosis of leukemias. Nevertheless, cases of acute myeloid leukemia with hand-mirror cells have been described in the literature and are often associated with chromosome 13 anomalies, mainly trisomy/tetrasomy 13. Hand-mirror cells have been described mostly, but not exclusively, in lymphoid malignancies, especially acute lymphoblastic leukemia, T-cell lymphomas, and multiple myeloma. Cytogenetic analysis demonstrated 13q deletion in 3 metaphases-46,XY,del(13)(q12q22)/46,XY. Flow cytometry analysis confirmed an increased number of myeloblasts (CD34 +, CD117 +, CD13 +, MPO +). Bone marrow aspirate revealed 34% blast cells with similar morphology. A high proportion of blast cells showed a hand-mirror morphology characterized by a cytoplasmic tail extending out from one pole of the nucleus (panels A and B, arrows) and harboring a few azurophilic granules and Auer rods (panels A and B, arrowheads). Peripheral blood smear revealed 35% blast cells with a moderate nuclear:cytoplasmic ratio and one or more nucleoli. We are the leading manufacturer and supplier of hand mirror to view our complete range pls. A complete blood count showed hemoglobin 9.2 g/dL, neutrophils 0.5 × 10 9/L, monocytes 1.3 × 10 9/L, and platelets 20 × 10 9/L. MOQ : 6 Piece(s) Brand Name : Mushkis Material : LAc Shape : All Shapes Style : Hand Mirror Place of Origin : India We are offering beautifully crafted Hand Mirrors. A 75-year-old man with a diagnosis of chronic myelomonocytic leukemia evolved with asthenia and worsening cytopenias.
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